Aortic aneurysms are often characterized by localized changes in aortic wall composition and structure that result from the degradation of elastin, loss of smooth muscle cell function, and remodeling of collagen. Correlations between wall composition and local mechanical properties can potentially provide insight into conditions that render a vessel susceptible to failure. Previous work has shown that chronic angiotensin-II infusion in ApoE-/- mice often results in dissecting aneurysms (Bersi et al. 2012). The objective of this work is to establish a new protocol able to characterize in vitro the local mechanical properties of arteries on the murine model.